What has Adjuvant Chemotherapy of Osteosarcoma Achieved? Discussion Paper
نویسندگان
چکیده
منابع مشابه
Role of Neo-Adjuvant Chemotherapy in the Treatment of Osteosarcoma
Osteosarcoma is a tumour characterized by the production of osteoid by malignant cells. The incidence is approximately 1 to 3 million/year. The incidence is slightly higher in males. Onset can occur at any age; however, primary high grade osteosarcoma usually occurs in the second decade of life. Historically patients with osteosarcoma were treated with immediate wide or radical amputation. Desp...
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Osteosarcoma is the most common primary malignant neoplasm of bone in children, adolescents and young adults. Prior to 1970, the outcome for patients with osteosarcoma was dismal, with only 10–20 % of patients achieving long-term survival. The improvement in survival over the past four decades, now approaching 75 %, has largely been due to the addition of adjuvant chemotherapy to surgery. Howev...
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PURPOSE Osteoporosis is currently receiving particular attention as a sequela in survivors of childhood osteosarcoma. The aim of this study was to evaluate bone mineral density (BMD) changes during methotrexate-based chemotherapy in children and adolescents with osteosarcoma. METHODS Nine patients with osteosarcoma were included in this retrospective study and compared with eight healthy cont...
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INTRODUCTION The mastectomy clinical pathway was developed to optimise the clinical care and cost management of breast cancer patients. The aim of this study was to prospectively assess the effect of the mastectomy pathway at the National University Hospital, Singapore over a 7-month period. MATERIALS AND METHODS A prospective study was carried out on all breast cancer patients admitted for e...
متن کاملneoadjuvant and adjuvant chemotherapy in osteosarcoma (the experience of horc in the shariati hospital)
background: osteosarcoma is the most common bone sarcoma, and the third most common malignancy in children and adolescents. before 1970, amputation was the sole treatment. eighty percent of patients died from metastatic diseases, most commonly in the lungs. over the past three decades, effective neoadjuvant (preoperative) and adjuvant (postoperative) chemotherapy protocols have improved the abi...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1983
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107688307601111